opened in to (verb) join: touch; border on
Sinonime: aggravation, annoyance, awkwardness, bothersomeness, cumbersomeness, difficulty, disadvantage, discomfort, disruption, disturbance, drawback, exasperation, fuss, hindrance, incommodity, nuisance, pain*, stew, trial, trouble, troublesomeness, uneasiness, unfitness, unhandiness, unsuitableness, untimeliness, unwieldiness, upset, vexation
Antonime: separate